Published in Vaccine Weekly, December 7th, 1998
Animals primed with a DNA vaccine encoding HIV-1 antigens and then boosted with a recombinant fowlpox virus (rFPV) vaccine expressing the same antigens were able to resist challenge. Protection appeared to be due to HIV-1 specific T-helper type 1 (Th1) immune responses.
"This study suggests a primary role for T-cell responses in protection from HIV-1 challenge," concluded Stephen J. Kent of the Macfarlane Burnet Center for Medical Research, Victoria, Australia, and colleagues.
Kent et al. reported their findings in the Journal of...
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