AIDS Vaccines

DNA Prime/Fowlpox Boost Yields Protective T-Cell Response

Published in Vaccine Weekly, December 7th, 1998

An HIV vaccine strategy showed that it can elicit potent T-cell responses in monkeys and mice.

Animals primed with a DNA vaccine encoding HIV-1 antigens and then boosted with a recombinant fowlpox virus (rFPV) vaccine expressing the same antigens were able to resist challenge. Protection appeared to be due to HIV-1 specific T-helper type 1 (Th1) immune responses.

"This study suggests a primary role for T-cell responses in protection from HIV-1 challenge," concluded Stephen J. Kent of the Macfarlane Burnet Center for Medical Research, Victoria, Australia, and colleagues.

Kent et al. reported their findings in the Journal of...

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Source: Vaccine Weekly (1998-12-07)

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