Published in Vaccine Weekly, December 7th, 1998
The virus infecting the animals could be passaged in vivo. However, it established only low-level, nonpathogenic infections. But the findings provide hope for an inexpensive new animal model for AIDS.
To this end the researchers are hoping to develop lines of transgenic cotton rats.
"Transgenic mice expressing human CD4, CXCR4, and CCR5 are made more permissible for HIV-1 entry and genomic incorporation of the provirus," wrote Raymond J. Langley of Virion Systems Inc., Rockville, Maryland, and colleagues. "Similar approaches in expressing the...
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