Molecular Biology

Meningococcus Structures Seen As Vaccine Key

Published in Vaccine Weekly, December 21st, 1998

Insights into the molecular biology of the meningococcus pathogen may help vaccines marshall innate antibacterial mechanisms.

Serogroup B Neisseria meningitidis is a leading cause of meningitis and fulminant septicemia all over the world, including the U.S. The bug enters the body via the respiratory system and manages to survive in the bloodstream where it multiplies, causing various forms of invasive disease.

The ability of this germ to survive potent antibacterial defenses has been traced to its capsule and to a bacterially expressed lipooligosaccharide (LOS) with terminal sialic-acid residues. Indeed, new N. meningitidis vaccines...

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Source: Vaccine Weekly (1998-12-21)

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