Hepatitis B

DNA-Vaccinated Woodchucks Chuck Hepatitis Infection

Published in Vaccine Weekly, December 28th, 1998

A DNA vaccine encoding both a core and surface antigen protected against hepatitis B infection in the woodchuck model.

The current hepatitis B virus (HBV) vaccine is based on the HBV surface antigen (HBsAg). However, not only does it fail to elicit protective immunity in 5 to 10 percent of vaccinees, it also fails to protect against HBV mutants bearing HBsAg variants. Thus a vaccine based on multiple determinants should be more effective - and it would work even better if it elicited HBV-specific cellular immunity as well as anti-HBV humoral responses.

To this end, Mengji Lu of the University of Essen, Germany, and colleagues developed two HBV DNA...

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Source: Vaccine Weekly (1998-12-28)

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