"The Effect of Epitope Variation on the Profile of Cytotoxic T Lymphocyte Responses to the HIV Envelope Glycoprotein."

According to the authors' abstract of an article published in International Immunology, "To address the relationship between viral and host factors during HIV infection, we analyzed the effect of viral mutations on T-cell responses in seropositive, asymptomatic HLA-A2⁺ individuals using four envelope (env)-specific peptides with the HLA-A*0201 binding motif. We showed that the natural sequence variation was frequent within epitopes located in the C-terminal region of the env glycoprotein and was largely responsible for a lower env-specific cytotoxic T lymphocyte (CTL) activity in the peptide-stimulated cultures. The highest CTL responses in vitro were induced with conserved...

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