Persistent Antigen Presentation with rAAV

Some researchers are hoping to call it an AIDS vaccine.

Recombinant adeno-associated virus (rAAV) is already known by gene-therapy researchers, who are exploring the use of its unique properties as a DNA delivery vehicle. Now vaccinologists hope to take advantage of AAV's unique properties in the quest for today's Holy Grail: an HIV vaccine.

To date, no experimental AIDS vaccine has succeeded in the induction of long-lasting HIV specific humoral responses without repeated boosting. But a preliminary experiment with macaque monkeys has shown that a single inoculation with rAAV carrying...

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