Vaccines (HBV)

Response to pre-S/S Vaccine Influenced by Genotype

Published in Vaccine Weekly, March 1st, 1999

It appears that immune response to a pre-S/S hepatitis B vaccine is influenced by the HLA genotype of the person being vaccinated.

In this study, A.B. McDermott and colleagues investigated the effects of single pre-S/S (Hepagene) revaccination in a large population of multiple 'S' vaccinated anti-HBs antibody nonresponder individuals (< 3 IU/l). Hepagene is a registered trademark of Hedeva Pharma Ltd.

"We investigated the influence of vaccine dose (5, 10, 20, and 40 micrograms/ml), number of previous 'S' containing vaccinations and the individuals HLA genotype on both B- and T-cell responses." McDermott et al. wrote ("Human Leukocyte Antigens...

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Source: Vaccine Weekly (1999-03-01)

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