Published in Vaccine Weekly, March 1st, 1999
It is widely believed that the most effective AIDS vaccine should capable of eliciting HIV specific cytotoxic lymphocyte (CTL) responses. Unfortunately, the genetic diversity of human leukocyte antigen (HLA) alleles means that an epitope that turns on CTL for one person does nothing in another.
Thus researchers are faced with the tedious task of finding the HIV CTL epitopes for each MHC type.
"HIV is a language. It's a lexicon of words, and there are many dialects," said Ann De Groot of Brown University, Providence, Rhode Island. "We are...
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