Published in Vaccine Weekly, March 29th, 1999
Gregory M. Glenn and colleagues of Walter Reed Army Institute of Research and IOMAI Corp., Washington, D.C., previously reported that transcutaneous immunization (TCI) with whole cholera toxin (CT) can carry vaccine antigens across intact skin.
They now report that TCI using CT or other bacterial ADP-ribosylating exotoxins (bAREs) can boost primary vaccination, elicit mucosal antibodies, and protect mice against systemic challenge with tetanus.
"TCI appears to offer a new method for the delivery of vaccines,...
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