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Hepatitis B Vaccine Adverse Events: Reporting Artifact?

Published in Vaccine Weekly, April 12th, 1999

The extraordinary reliability of health-care workers may be a problem for hepatitis B (HB) vaccine safety studies.

Preliminary data from a U.S. Centers for Disease Control and Prevention (CDC) study show that adults report adverse events after HB vaccination at a higher rate than after adult tetanus/diphtheria vaccination.

The finding is of obvious concern following isolated but harrowing reports of permanent paralysis in previously healthy adults following HB vaccination. But the man charged with tracking U.S. vaccine safety suggested that the finding may be an artifact of the CDC's Vaccine Adverse Event Reporting System (VAERS).

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