Published in Vaccine Weekly, April 26th, 1999
Antibodies to toxins are thought to protect against disease. Whole toxins are far more immunogenic than toxin subunits. But administration of whole toxins themselves is of course too toxic.
"We're trying to get nontoxic forms of toxic genes in an economically feasible way," Atreya said. "Our hypothesis is that cells made to express a toxin gene will either evolve to tolerate the gene or evolve attenuating mutations in the...
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