Conference Coverage (2nd Annual Vaccine)

Technique Takes Toxicity Out of Toxins

Published in Vaccine Weekly, April 26th, 1999

A novel technique creates nontoxic toxins for use in vaccines.

Antibodies to toxins are thought to protect against disease. Whole toxins are far more immunogenic than toxin subunits. But administration of whole toxins themselves is of course too toxic.

In a proof-of-principle experiment, C.D. Atreya of the U.S. Food and Drug Administration (FDA) has created a nontoxic rotavirus toxin.

"We're trying to get nontoxic forms of toxic genes in an economically feasible way," Atreya said. "Our hypothesis is that cells made to express a toxin gene will either evolve to tolerate the gene or evolve attenuating mutations in the...

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Source: Vaccine Weekly (1999-04-26)

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