"Development of HIV/AIDS Vaccine Using Chimeric gag-env Virus-Like Particles."

According to the authors' abstract of an article published in Biological Chemistry, "We attempted to develop a candidate HIV/AIDS vaccine by using unprocessed HIV-2 gag Pr45 precursor protein. We found that a 45 kDa unprocessed HIV-2 gag precursor protein (pr45), with a deletion of a portion of the viral protease, assembles as virus-like particles (VLP). We mapped the functional domain of HIV-2 gag VLP formation in order to find the minimum length of gag protein to form VLP. A series of deletion mutants was constructed by sequentially removing the C-terminal region of HIV-2 gag precursor protein and expressed truncated genes in Spodoptera frugiperda (SF) cells by infecting...

Want to see the full article?

• Purchase this article for only $3.00