AIDS Vaccines
Protection, HIV Clearance with rgp120 ISCOM
Published in Vaccine Weekly, May 17th, 1999
A Dutch/Swedish/U.S. research team compared T-helper immune responses in groups of rhesus macaque monkeys given one of three different envelope-based HIV vaccines. The vaccines used the HIV-1SF2 gp120 envelope glycoprotein expressed in vivo via DNA immunization (gene-gun administered); delivered as a subunit protein with MF59 adjuvant; or incorporated into ISCOMs.
"The best immune response to the gp120SF2 antigen was obtained by incorporating this antigen into ISCOMs," reported Ernst. J. Verschoor of the...
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Source: Vaccine Weekly (1999-05-17)
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