Published in Vaccine Weekly, May 24th, 1999
The understanding of dengue virus pathogenesis has been impeded by the lack of both in vitro and in vivo models of disease. The study of viral factors involved in the production of dengue hemorrhagic fever (DHF), versus the more common dengue fever (DF), have been limited to indirect clinical and epidemiologic associations.
Katrin C. Leitmeyer, Southwest Foundation for Biomedical Research, San Antonio, Texas, and colleagues developed a method for comparing dengue type 2 genomes from patient plasma ("Dengue Virus Structural...
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