Colorectal Cancer Vaccine
"Active Specific Immunotherapy for Metastatic Colorectal Carcinoma: Phase I Study of an Allogeneic Cell Vaccine Plus Low-Dose Interleukin-1 alpha."
Published in Vaccine Weekly, June 28th, 1999
According to the authors' abstract of an article published in Journal of Immunotherapy, "A vaccine consisting of four allogeneic colon carcinoma cell lines (DLD-1, HCT116, WiDr, and T83) mixed with the adjuvant DETOX (Mycobacterium phlei cell wall and Salmonella minnesota lipid A) was administered to 25 patients with low-volume metastatic colorectal carcinoma. The first eight patients received vaccine only, given intradermally on three occasions at three-week intervals. Subsequent patients also received subcutaneous interleukin-1 alpha (IL-1 alpha), 0.3-0.5 (mu)g/m2 per day for eight days after each vaccination in an outpatient setting. Vaccine alone caused...
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Source: Vaccine Weekly (1999-06-28)
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