AIDS Pathogenesis

HIV Sails into Cells on Gb3 "Raft"

Published in Vaccine Weekly, July 26th, 1999

The AIDS virus boards a lipid raft that keeps it afloat as it searches for a way into a cell, a French research team suggests.

According to their hypothesis, the raft is made up of glycosphingolipid microdomains. Once it has bound to a CD4 cell receptor, HIV sails along the cell surface on the glycosphingolipid, dragging along the CD4 receptor like a dinghy until it finds an appropriate chemokine coreceptor. The coreceptor - CCR5 or CXC4R - then displaces the glycosphingolipid and begins the membrane-fusion process whereby the virus gains entry to the cell.

In a series of in vitro experiments, Djali Hammache of the St. Jerome Faculty of Sciences,...

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Source: Vaccine Weekly (1999-07-26)

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