Vaccine Development
Rational Development of New TB Vaccine
Published in Vaccine Weekly, July 26th, 1999
Pasteur Institute researchers Mary Jackson and colleagues created two potential tuberculosis vaccine strains (MYC1551 and MYC1552) by disrupting genes needed by the bacteria for purine biosynthesis.
Similar attenuations - resulting in auxotrophic mutants unable to normally obtain nourishment - have been explored with other bacterial pathogens. These mutants are attenuated in vivo but retain their immunogenicity.
Jackson et al. compared the two vaccines to bacillus Calmette-Guerin...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Vaccine Weekly
Source: Vaccine Weekly (1999-07-26)
More Articles from Vaccine Weekly
- Conference Coverage (EULAR)
Tolerance As Arthritis Therapy - AIDS Pathogenesis
HIV Sails into Cells on Gb3 "Raft" - Conference Coverage (ASCO)
HPV Vaccine Enters Clinical Trial Stage - Mucosal
Nasal Immunization Elicits Ab in Lung, Urogenital Tract - Polio
Wars Threaten Polio Eradication Plan - Immunization
HBV Vaccine Inactivity Assessed in Pregnant Women - More from this issue of Vaccine Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
