Rotavirus
"Rotaviruses Detected by Reverse Transcription Polymerase Chain Reaction in Acute Gastroenteritis During a Trial of Rhesus-Human Reassortant Rotavirus Tetravalent Vaccine: Implications for Vaccine Efficacy Analysis. DOUBLE
Published in Vaccine Weekly, August 16th, 1999
According to the authors' abstract of an article published in Journal of Clinical Virology, "Background: Rotaviruses are routinely diagnosed by detection of rotavirus antigen in stools using an enzyme immunoassay (EIA). A sensitive method, like reverse transcription polymerase chain reaction (RT-PCR), may reveal more rotaviruses, but the clinical significance of such findings is not well established. Objectives: To study whether RT-PCR can detect more episodes of rotavirus-associated gastroenteritis than EIA and to determine how rotavirus RT-PCR findings might change efficacy analysis of a rotavirus vaccine trial, in which the outcome measure was rotavirus...
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Source: Vaccine Weekly (1999-08-16)
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