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Pneumococcal Infection

"Intranasal Immunization With Pneumococcal Polysaccharide Conjugate Vaccines Protects Mice Against Invasive Pneumococcal Infections."

Published in Vaccine Weekly, September 6th, 1999

According to the authors' abstract of an article published in Infection and Immunity, "Host defenses against Streptococcus pneumoniae depend largely on opsonophagocytosis mediated by antibodies and complement. Since Pneumococcus is a respiratory pathogen, mucosal immune responses may play a significant role in the defense against pneumococcal infections. Thus, mucosal vaccination may be an alternative approach to current immunization strategies, but effective adjuvants are required. Protein antigens induce significant mucosal immunoglobulin A(IgA) and systemic IgG responses when administered intranasally (i.n.) with the glyceride-polysorbate based adjuvant RhinoVax (RV)...

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