Published in Vaccine Weekly, September 13th, 1999
The emergence in vaccinated individuals of hepatitis B virus (HBV) mutants with amino acid substitutions within the a determinant of the surface protein has raised the possibility that such variants represent neutralization escape mutants.
In earlier studies, N. Ogata and colleagues at the U.S. National Institutes of Health demonstrated that one such mutant HBV, strain AS, with an arginine substituted for glycine at surface gene codon 145, was infectious and pathogenic in seronegative chimpanzees.
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