Pathogenesis

Nef: HIV's Siren Lures T Cells to their Doom

Published in Vaccine Weekly, September 20th, 1999

Like a siren singing from dangerous reefs, HIV lures uninfected T cells into hotbeds of viral activity.

Once the virus has attracted the cells, it sings a different song - one which activates the cells and makes them ready for infection.

New studies resolve a paradox of HIV infection: the virus almost always is transmitted by macrophage-tropic viral strains, but can replicate only within lymphocytes. The studies show that early expression of the HIV nef gene within infected macrophages causes the cells to excrete chemokines that attract lymphocytes. Nef also causes the cells to produce a lymphocyte-stimulating factor that activates T cells so that...

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Source: Vaccine Weekly (1999-09-20)

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