"Cytotoxic T Lymphocytes That Recognize Decameric Peptide Sequences of Retinoblastoma Binding Protein 1 (RBP-1) Associated with Human Breast Cancer."

According to the authors' abstract of an article published in British Journal of Cancer, "Retinoblastoma binding protein 1 (RBP-1) is a 143-kDa nuclear phosphoprotein that promotes cell growth by inhibiting the product of retinoblastoma tumour suppressor gene (pRB). We recently found that RBP-1 contains KASIFLK, a heptameric peptide (250-256) recognized by human antibodies and overexpressed by breast cancer cells. In the present study, we demonstrate that human T cells stimulated with RBP-1 decameric peptides containing KASIFLK can kill human breast cancer cells. These decamers, GLQKASIFLK (247-256) and KASIFLKTRV (250-259), have anchor motifs for both HLA-A2 and HLA-AS. Peripheral...

Want to see the full article?

• Purchase this article for only $3.00