SIV Vaccines
"Protection by Live, Attenuated Simian Immunodeficiency Virus Against Heterologous Challenge."
Published in Vaccine Weekly, October 25th, 1999
According to the authors' abstract of an article published in Journal of Virology, "We examined the ability of a live, attenuated deletion mutant of simian immunodeficiency virus (SIV), SIVmac239 Delta 3, which is missing nef and vpr genes, to protect against challenge by heterologous strains SHIV89.6p and SIVsmE660. SHIVS9.6p is a pathogenic, recombinant SIV in which the envelope gene has been replaced by a human immunodeficiency virus type 1 envelope gene; other structural genes of SHIV89.6p are derived from SIVmac239. SIVsmE660 is an uncloned, pathogenic, independent isolate from the same primate lentivirus subgrouping as SIVmac but with natural sequence variation in all structural...
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Source: Vaccine Weekly (1999-10-25)
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