TB Vaccines
Cytokines Mediate Immunity to TB
Published in Vaccine Weekly, November 22nd, 1999
In this study, I.S. Leal and colleagues from Portugal's University of Porto examined the role of cytokines in the development of gamma interferon (IFN-gamma)-secreting protective T cells following immunization with a culture filtrate subunit vaccine against Mycobacterium tuberculosis containing the adjuvant dimethyldioctadecylammonium bromide (DDA).
Depletion of either interleukin-6 (IL-6) or IL-12 with specific neutralizing antibodies during vaccination reduced the priming of T cells for antigen-specific...
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Source: Vaccine Weekly (1999-11-22)
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