Published in Vaccine Weekly, December 27th, 1999
J.A. Berzofsky and colleagues report on several approaches to develop enhanced vaccines for chronic viral infections such as HIV and hepatitis C virus (HCV). Selected epitopes were used to avoid potentially harmful immune responses.
Linkage between helper and cytotoxic T-lymphocyte (CTL) epitopes was found to be important. The researchers developed an "epitope enhancement" approach modifying the sequences of epitopes to make more potent vaccines, including examples for HIV and HCV epitopes presented by murine...
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