Vaccine Development

U.S. NIH Researchers Report on Engineered Vaccine Research

Published in Vaccine Weekly, December 27th, 1999

Researchers from the U.S. National Institutes of Health are exploring efforts to improve engineered vaccines for HIV and hepatitis C virus.

J.A. Berzofsky and colleagues report on several approaches to develop enhanced vaccines for chronic viral infections such as HIV and hepatitis C virus (HCV). Selected epitopes were used to avoid potentially harmful immune responses.

Linkage between helper and cytotoxic T-lymphocyte (CTL) epitopes was found to be important. The researchers developed an "epitope enhancement" approach modifying the sequences of epitopes to make more potent vaccines, including examples for HIV and HCV epitopes presented by murine...

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Source: Vaccine Weekly (1999-12-27)

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