Atherosclerosis

New Research Illustrates Protein Involvement

Published in Vaccine Weekly, December 27th, 1999

New research demonstrates that the cholesteryl ester transfer protein (CETP) can promote atherosclerosis, thus supporting the novel vaccine approach to preventing or treating that disease now under development by Avant Immunotherapeutics, Inc., the company says.

A study published in the December 1999 issue of Nature Medicine by researchers from Boston University School of Medicine and Avant described the creation of a transgenic rat model that carries the human gene for CETP in a rat strain that develops high blood pressure. As they aged, such rats developed severely high cholesterol and triglyceride levels, atherosclerotic lesions, myocardial infarctions (heart...

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Source: Vaccine Weekly (1999-12-27)

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