Functional Genomics

Learning Which Proteins React With One Another

Published in Vaccine Weekly, January 19th, 2000

Lost amid the fanfare greeting new DNA sequencing milestones is the less glamorous fact that eye-glazing streams of As, Cs, Ts, and Gs, per se, reveal little about how a creature works.

In the January 7, 2000, issue of Science, scientists at Massachusetts General Hospital and Harvard Medical School (HMS) describe how they have tested a way of discovering which proteins interact with one another.

The method uses a high-throughput version of a standardized assay to generate information about hundreds of proteins in a single experiment. It is the first functional genomics study that attempts to reveal the protein-protein interactions in the tiny...

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Source: Vaccine Weekly (2000-01-19)

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