Cancer Vaccines

Increased Dendritic Cells Increase Vaccine Efficacy

Published in Vaccine Weekly, January 26th, 2000

Procedures which increase the number of circulating dendritic cells (DCs) improve the efficacy of cancer vaccines, researchers from the United States reported.

"DCs initiate primary and stimulate secondary T-cell responses," wrote J. E. Janik and colleagues from the U.S. National Cancer Institute, Maryland. "We conducted a phase I trial of tumor necrosis factor (TNF-alpha) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with cancer to increase DCs in peripheral blood or skin."

According to the researchers, their idea was based on in vitro data that showed that CD34⁺ hematopoietic precursors require these...

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Source: Vaccine Weekly (2000-01-26)

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