Ebola

New Monoclonal Antibodies Combat Virus in Mice

Published in Vaccine Weekly, March 15th, 2000

The deadly Ebola virus didn't kill laboratory mice protected by newly developed monoclonal antibodies to the virus glycoprotein, report U.S. army medical researchers.

J.A. Wilson and colleagues, writing in the journal Science, said the antibodies protected mice when administered either before or after a viral challenge ("Epitopes involved in antibody-mediated protection from ebola virus," Science, March 3, 2000).

Subsequent analyses helped pinpoint specific groups of amino acids that seemed to allow Ebola glycoprotein to bind with some of the antibodies. One of these groups is conserved among all Ebola viruses known to cause lethal...

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Source: Vaccine Weekly (2000-03-15)

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