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Substance Abuse

Anti-Cocaine Vaccine Produces Antibodies and Is Safe

Published in Vaccine Weekly, March 22nd, 2000

A therapeutic cocaine vaccine designed to suppress the high addicts get from taking cocaine is safe and produced cocaine antibodies in humans, a Yale University study finds.

Thomas Kosten, MD, principal investigator on the Phase 1 study, and his team administered the vaccine to 34 former cocaine abusers living in a residential treatment facility.

The vaccine, TA-CD, is designed to generate drug-specific antibodies, which bind to cocaine and prevent it from traveling to the brain from the bloodstream. This neutralizes its psychoactive effect.

"The vaccine is very safe and we did not observe any major side effects," said...

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