Tuberculosis

HLA-Restricted Immune Response Relevant to Vaccine Design

Published in Vaccine Weekly, March 22nd, 2000

HLA-restricted immune responses are relevant to the design of mycobacterial vaccines, researchers from Kuwait reported.

"Identification of mycobacterial antigens that are recognized by CD4⁺ Th1 cells in HLA-nonrestricted manner or in association with multiple allelic products is required to develop universally effective vaccines against mycobacterial diseases," wrote A.S. Mustafa and colleagues, Kuwait University, Kuwait. "Our studies in this direction have shown that several recombinant mycobacterial antigens of cytosolic and culture filtrate origin are recognized by CD4⁺ Th1 cells."

Mustafa et al. published their study in...

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Source: Vaccine Weekly (2000-03-22)

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