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Combination Therapy

Antitumor Immunity Induced by Indomethacin and Cancer Vaccine

Published in Vaccine Weekly, March 22nd, 2000

Combination immunotherapy and indomethacin induced anticancer immunity in murine cancer models, researchers from Israel reported.

"Irradiated tumor cells given, together with indomethacin, to syngeneic mice induced an antitumor response and conferred protection against a challenge of a lethal dose of murine mammary (4T1) and lung (3LL) carcinoma cells," wrote S. Morecki and colleagues, Hadassah University Hospital, Israel. "Continuous administration of indomethacin was crucial throughout the entire period of immunization and challenge, as no protection was achieved when the drug was given during only one of these procedures."

Morecki et al....

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