HIV Vaccines

Epitopes Recognized by Monoclonal Antibodies May Advance HIV Vaccine Search

Published in Vaccine Weekly, March 22nd, 2000

Epitopes recognized by three monoclonal antibodies may hold the key to an effective anti-HIV vaccine.

Although maternal HIV-1 transmission occurs during gestation, intrapartum and postpartum (by breastfeeding), 50%-70% of all infected children seem to acquire HIV-1 shortly before or during delivery.

"Epidemiological evidence indicates that mucosal exposure is an important aspect of intrapartum HIV transmission," researcher T.W. Baba and colleagues from the Dana Farber Cancer Institute wrote ("Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection," Nature Medicine,...

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Source: Vaccine Weekly (2000-03-22)

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