Published in Vaccine Weekly, April 19th, 2000
"Entrapment of subunit antigens in biodegradable microspheres for oral vaccination has been a major research area for over ten years during which there has been very little progress in achieving reproducible potent immunization in a reliable dosage form," said David Brayden and colleagues, Trinity College, Ireland.
"In the late 1980s and early 1990s much of the literature suggested that a wide range of PLGA-entrapped antigens could be administered orally leading to successful mucosal immunization and protection...
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