Published in Vaccine Weekly, April 19th, 2000
"Peptide vaccination induces T-cell activation and cytotoxic T-cell development," wrote J.T. Tan and colleagues, Emory University, Georgia, USA. "In an effort to understand what factors can improve immune responses to peptide vaccination, the role of 4-1BB (CD137) costimulation was examined, since 4-1BB has been shown to promote T-cell responses in other systems."
Tan et al. published their study in the Journal of Immunology ("4-1BB costimulation is required for protective antiviral immunity after peptide vaccination," J...
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