Published in Vaccine Weekly, April 19th, 2000
"Expression of Gag proteins for vaccines has been hampered by the fact that its expression is dependent on the HIV rev protein and the Rev-responsive element, the latter located on the env transcript," stated J. Zurmegede and colleagues ("Increased expression and immunogenicity of sequence-modified human immunodeficiency virus type 1 gag gene," J Virol, 2000;74(6):2628-2635).
To overcome this problem, the...
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