Cancer Vaccines

Intradermal RNA Inoculation Induces Anti-Tumor Immunity

Published in Vaccine Weekly, May 24th, 2000

Intradermal RNA inoculation or vaccination with epidermal cells pulsed with tumor-derived RNA induces anti-tumor immunity in a murine model, according to Cornell University researchers.

"The skin is well-suited to serve as a substrate for vaccination strategies," stated R.D. Granstein and colleagues, Cornell University, New York. "In this regard, epidermal cells exposed to granulocyte-macrophage colony-stimulating factor can, upon subcutaneous injection into naive mice, present a soluble extract of tumor as a source of tumor-associated antigens for the induction of in vivo anti-tumor immunity. Use of RNA for immunization has a potential advantage over this...

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Source: Vaccine Weekly (2000-05-24)

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