Suicide Gene Therapy

Treatment of Malignant Gliomas Tested in Animal Model

Published in Vaccine Weekly, June 7th, 2000

Improving microglia response might boost efficacy of herpes simplex virus thymidine kinase (HSV-tk) gene transfer and ganciclovir administration in treatment of gliomas, researchers suggest.

A.M. Sandmair and colleagues, University of Kuopio, Finland explained: "To understand tissue responses and possible ways to improve the treatment effect, we studied tumor growth, tissue reactions, and survival time after HSV-tk/GCV treatment in a syngeneic BT4C rat glioma model by mixing various ratios of stably transfected HSV-tk-expressing BT4C-tk glioma cells with wild-type BT4C glioma cells (percentage of BT4C-tk cells: 0%, 1%, 10%, 30%, 50%, and 100%), followed by injection...

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Source: Vaccine Weekly (2000-06-07)

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