Cancer Gene Therapy

Antisense Enhances Immunogenicity of Tumor Cell Vaccine

Published in Vaccine Weekly, June 7th, 2000

Cotransfection with genes encoding antisense insulin-like growth factor-1 and B7.1 molecules can enhance the immunogenicity of tumor cell vaccines.

"Insulin-like growth factor-1 (IGF-1) is expressed in many tumor cell lines and has a role in both normal cell proliferation and in the growth of cancers," stated Y.J. Liu and colleagues, Second Military Medical University, International Cancer Institute, China. "Tumor cells transfected with a vector encoding an IGF-1 antisense cDNA transcriptional cassette driven by the mouse metallothionein-l promoter become immunogenic and lose their tumorigenicity in syngeneic animals."

According to the researchers,...

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Source: Vaccine Weekly (2000-06-07)

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