Vector Re-Administration

Transient Immunosuppression Allows Repeated Adenoviral Vector Delivery

Published in Vaccine Weekly, June 28th, 2000

Antibody blockade of T cells allows re-administration of adenoviral gene therapy vectors, researchers in France and The Netherlands reported.

"In many instances, repeated administrations of adenoviral gene therapy vectors will be required to obtain therapeutic levels of the protein of interest," said Helene Haegel-Kronenberger and colleagues from Transgene S.A., France, Utrecht University and Tanox Pharmaceuticals, The Netherlands. "Re-administration of adenoviral vectors into immunocompetent hosts is hampered by the development of a neutralizing humoral response against adenoviral proteins. Transient immunosuppression of patients may be necessary to decrease or...

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Source: Vaccine Weekly (2000-06-28)

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