Pathogenesis

How E. coli Put a Death Grip on Intestinal Cells

Published in Vaccine Weekly, July 12th, 2000

A team of molecular biologists and X-ray crystallographers has produced the first detailed picture showing how pathogenic Escherichia coli bacteria achieve a molecular death grip on intestinal cells.

The structure may reveal critical steps in E. coli attachment that scientists can attack with drugs designed to thwart infection by halting bacterial binding.

The E. coli bacteria include the enteropathogenic strains that are a major cause of childhood diarrhea in developing countries, killing close to one million children each year due to dehydration and other complications. This family of pathogens also includes E. coli...

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Source: Vaccine Weekly (2000-07-12)

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