Malaria Vaccines

Antibodies Against Thrombospondin-Related Anonymous Protein are Ineffective

Published in Vaccine Weekly, July 26th, 2000

Antibodies against thrombospondin-related anonymous protein (TRAP) are unable to inhibit Plasmodium sporozoite infection in vivo, researchers in the United States reported.

"TRAP, a candidate malaria vaccine antigen, is required for Plasmodium sporozoite gliding motility and cell invasion," explained S. Gantt and colleagues, New York University. "For the first time, the ability of antibodies against TRAP to inhibit sporozoite infectivity in vivo is evaluated in detail."

Gantt et al. published their study in the journal Infection and Immunity ("Antibodies against thrombospondin-related anonymous protein do not inhibit...

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Source: Vaccine Weekly (2000-07-26)

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