Melanoma

Polynucleotide Vaccine from Melanoma Antigen Under Development

Published in Vaccine Weekly, July 26th, 2000

Researchers in the United States are developing a polynucleotide vaccine from melanoma antigens, which recognize MART-1, for evaluation in clinical trials.

"MART-1, a melanoma antigen recognized by T cells-1, is a melanocyte lineage-differentiation antigen expressed only in melanocytes and melanoma cells," stated S.W. Lee and colleagues, University of Alabama. "This protein is recognized by many T-lymphocyte lines that are human leukocyte antigen (HLA)-A2 restricted and melanoma reactive. These observations have culminated in an array of clinical trials of MART-1 immunization using recombinant viruses or MART-1 immunodominant peptides."

Lee et al....

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Source: Vaccine Weekly (2000-07-26)

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