Colorectal Cancer

Photoimmunotherapy Targets Hepatic Metastases with Antibody

Published in Vaccine Weekly, August 30th, 2000

Researchers in the United States and Italy have developed a photoimmunotherapy protocol that targets hepatic metastases using a monoclonal antibody (MAb).

"Photoimmunotherapy (using a MAb-targeted photosensitizer and red light) may be a strategy to overcome the limitations inherent in photodynamic therapy of liver tumors," reported M.R. Hamblin and colleagues from several institutions in the United States and Italy. "The aims were 1) to test the efficacy of selective treatment of hepatic metastases of colorectal cancer in an orthotopic murine xenograft using the murine MAb 17.1A conjugated to the photosensitizer chlorin e6, and 2) to compare the tumor response after...

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Source: Vaccine Weekly (2000-08-30)

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