Published in Vaccine Weekly, September 13th, 2000
"Immunostimulatory DNA sequences (ISS) are a potent Th1 adjuvant," stated H. Tighe and colleagues, University of California at San Diego. "We hypothesized that conjugation of ISS to protein antigens would strongly enhance their immunogenicity because both antigen and adjuvant (ISS) would be delivered to the same locale/antigen-presenting cell. To test this hypothesis, we conjugated a 22-mer immunostimulatory oligodeoxynucleotide (ISS-ODN) to two test antigens of differing intrinsic immunogenicity, namely Escherichia...
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