Vertical Transmission

In utero DNA Vaccine Delivery Induces Fetal Protective Immunity in Animal Model

Published in Vaccine Weekly, September 27th, 2000

Members of the Veterinary Infectious Disease Organization (VIDO) reported that fetal immunization by a DNA vaccine delivered into the amniotic fluid may be a way of reducing vertical transmission of infectious diseases.

"Infectious diseases remain the major cause of infant morbidity and mortality," stated Volker Gerdts and colleagues. "In 1995, nearly five million newborn children died during the first week of life from infection with e.g., herpes simplex virus, HIV, hepatitis B virus, human cytomegalovirus, or Group B strep."

According to the researchers, vertical transmission occurs during gestation, and intra- or postpartum. Typically, to...

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Source: Vaccine Weekly (2000-09-27)

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