Human Papillomavirus

Recombinant Vaccinia Virus Induces HPV-Caused Tumor Regression

Published in Vaccine Weekly, November 1st, 2000

Researchers in Mexico evaluated a recombinant vaccinia virus containing the papilloma E2 protein for its ability to eradicate papilloma-based tumors.

"Human papillomavirus infection is associated with cervical cancer," stated C. Rosales and colleagues, National Autonomous University of Mexico. "The E6 and E7 papillomavirus proteins are normally required for the maintenance of the malignant phenotype. Expression of these proteins in infected cells is negatively regulated by the binding of the papilloma E2 protein to the long terminal control region of the papilloma virus genome."

According to the researchers, the E2 protein also promotes cell cycle...

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Source: Vaccine Weekly (2000-11-01)

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