HIV Vaccines

HIV-1 Antigen and Immunostimulatory Sequence Stimulate Antibody Responses

Published in Vaccine Weekly, November 8th, 2000

by Michelle Marble -- Researchers in the United States report that they may have developed the ideal candidate HIV-1 vaccine for testing in both primates and humans.

"We hypothesized that HIV-1 specific CD4⁺ T helper immune responses could be enhanced when an immunostimulatory sequence (ISS) was combined with a whole-killed gp120-depleted HIV in Incomplete Freund's Adjuvant (IFA)," stated Ronald B Moss and colleagues from The Immune Response Corp., California. "We also reasoned that if such T helper responses were sufficient, then such a combination might also induce HIV specific CD8 T-cell immune responses."

Moss et al. presented data...

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Source: Vaccine Weekly (2000-11-08)

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