HIV Vaccines

B7 Co-Stimulatory Requirements Differ According to Vaccine Type

Published in Vaccine Weekly, November 15th, 2000

Requirements for B7 co-stimulation differ according to whether the vaccine is a DNA vaccine, a protein vaccine, or a recombinant poxvirus vaccine, a recent study indicates.

"Whether B7-1 and B7-2 have distinct functions for eliciting immune responses to antigens that are presented to the immune system by intracellular and extracellular antigen processing pathways is an unresolved question," stated S. Santra and colleagues, Harvard University, Massachusetts. "To investigate this issue we compared the humoral and cellular immune responses elicited by immunizing wild-type, B7-1^-/- and B7-2^-/- mice with either HIV-1 gp120 plasmid DNA, recombinant...

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Source: Vaccine Weekly (2000-11-15)

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