Respiratory Syncytial Virus

Blocking Hairpin Formation Can Inhibit RSV

Published in Vaccine Weekly, January 10th, 2001

Blocking hairpin formation of the human respiratory syncytial virus (HRSV)-F protein inhibits entry of the virus and thus suggests an approach for development of a vaccine or chemoprophylaxis against the virus, say Massachusetts Institute of Technology researchers.

"Two heptad-repeat regions within the HRSV F sequence were predicted by the computer program learncoil-vmf," said X. Zhao and colleagues, writing in the Proceedings of the National Academy of Sciences - USA.

"These regions are thought to form trimers of hairpin-like structures, similar to those found in the fusion proteins of several enveloped viruses. The hairpin structure likely...

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Source: Vaccine Weekly (2001-01-10)

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